The Transcension Hypothesis, as presented here by John Smart, proposes a model of the universe in which an all-encompassing process of evolutionary development guides any sufficiently advanced civilization into what may be called “inner-space”: a computationally optimal domain of increasingly dense, productive, miniaturized, and efficient scales of Space, Time, Energy, and Matter (STEM).
This process, estimated by Smart to complete ~600 years after technological singularity, is an extension of the idea that virtual minds existing at the nano and femto scales will continue compressing their STEM until approximating a black hole-like optimal computational environment.
Based upon a set of varied assumptions, Smart estimates that the costs (both evolutionarily and developmentally) after entering such an environment will outweigh the benefits of reaching out to other non-transcendent species, hence our lack of any contact with any other highly advanced civilizations. His assumptions have their root in evolutionary biology, and imply that there exists a natural goal of fostering a maximally diverse set of transcendent species.
Smart’s assumptions are broad, however, he proposes a method of testing his hypothesis based in the trending prevalence of electromagnetic frequencies. See additional thoughts by Smart here via blog post.